Cerebral edema (swelling of the brain) commonly occurs when a person with MSUD is in metabolic crisis. As cerebral edema has the potential to cause brain damage, prevention and effective treatment of cerebral edema is a major focus of clinicians. The precise mechanism by which high levels of leucine damage the brain are not known. This study used rats to look at the effect of branched-chain amino acids (BCAAs) on the brain, and examined the effect of dexamethasone, a steroid drug which has been found effective in treating cerebral edema resulting from brain tumors and other causes.

The authors demonstrated that elevated BCAA levels increase the permeability of the brain, allowing greater amounts of fluid and small molecules to enter. They also found that when rats were given dexamethasone, permeability of the brain, brain swelling and brain damage was reduced.

My Trip To Israel

I met Avi, Dikla, and Tamar Starr last year at the MSUD Symposium in Raleigh, NC. Tamar, classic MSUD, was 2 ½ at the time, and they invited me to come to Israel and stay with them for a year.

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I want to help out, but I don’t know how

Have you ever wanted to help out the MSUD Family Support Group but were unsure about how to contribute? The MSUD Family Support Group is actively looking for volunteers to assist with advocacy and fundraising efforts.

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Our Story

On April 23 2015, our precious firstborn son Eliyahu Tuvia was born in Jacksonville, FL. All seemed well and we took our bundle of joy home.

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Adjusting Protein In An Adult With MSUD

A little over a year ago, in January, Jeff was just not himself. He had limited energy, was not eating well, and often appeared slightly agitated.

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20th Annual White Horse Beach Charity Golf Tournament

On July 29, 2017 Charlie O’Rouke and his committee held the 20th Annual White Horse Beach Charity Golf Tournament.

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Indigo Charlie Mays - Variant MSUD Age 4

Meet our girl Indigo Charlie Mays. After a smooth pregnancy and delivery, she was born on July 21st, 2013 in Seattle, WA.

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A Child's Life

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